Assistant Professor Chulabhorn International College of Medicine, Thammasat University Klong Luang, Pathum Thani, Thailand
Abstract: Adipose-derived mesenchymal stem cells have gained significant attention in regenerative medicine due to their potential therapeutic applications. Providing their paracrine signaling regulating recipient cells as the extracellular vesicles (EVs) exhibit rejuvenation and immunomodulation properties. Autologous EVs derived from a person’s adipose tissue hold significant therapeutic potential due to their compatibility with an individual’s immune system, reducing the risk of adverse reactions. The differences between EVs derived from young and aged adipose tissues MSCs highlight the importance of understanding age-related changes in the EVs composition and function. The different age female donors for adipose tissues were obtained from 28 to 60 years old; we discussed the shift in MSCs proliferation, differentiation potential, regenerative effect, and immunomodulatory properties. Moreover, the differences in EVs characteristics, diverse cargo of bioactive molecules, and potency for skin rejuvenation and aging have addressed the importance of considering age-related factors when utilizing the autologous adipose-derived MSC and its extracellular vesicles for aesthetic dermatology and regenerative medicine.
Funding Source: 1. Thailand Science Research and Innovation Fundamental Fund Fiscal year 2025 2. Chulabhorn International College of Medicine Research Grant 3. Stemsciences Co., Ltd.
