Post-doctoral Fellow The University of Hong Kong, Hong Kong
Abstract: Our research endeavors to reveal novel genetic factors and mechanisms involved in placental aging, with a particular emphasis on the function of specific genes identified during trophoblast stem cell differentiation. Initial findings suggest the involvement of several genes that play a critical role in the aging of reproductive tissues. Our previous research identified unique gene expression patterns shared between trophoblast differentiation and the aging process, such as CDK7, TFCP2L1, CDO1, NR6A1, and TACSTD2. To further explore the significance of these genes in cell senescence, we plan to conduct gene knockout experiments in trophoblast stem cells, followed by differentiation of these knockout cell lines into EVT and ST. Our research aims to uncover new mechanisms related to placental aging through gene editing and high-throughput sequencing technologies. Situated at the intersection of reproductive biology and genomics, our work provides fresh perspectives on the genetic foundations of aging within the reproductive system. The outcomes of this research could potentially lead to the development of innovative strategies to support healthy aging in women and enhance our understanding of the intricate genetic processes governing reproductive aging.
