Abstract: The recent widespread of Monkeypox Virus (MPXV) infection worldwide has caught global attention on the impact of this viral pandemic. Although MPXV infection was long identified decades ago, its re-emergence in 2022 has caused the declaration of Public health emergency of international concern. Unfortunately, the current available treatment strategies are not effective in treating MPXV infections. Here, we identified a new cell model for dissecting monkeypox infections, which has a high virus susceptibility and cell survivability after infection. This novel platform could bring new and invaluable insights into the current drug development for MPXV infections, as well as other viral infections.
Funding Source: This project is supported by the National Key Research and Development Program of China (nos. 2022YFA1105401); Health@InnoHK, Innovation Technology Commission; HKSAR
