Innovation Showcases
Human induced pluripotent stem cell (hiPSC)-derived models provide physiologically relevant, reproducible platforms for modeling neurological and retinal diseases and advancing drug discovery. STEMCELL Technologies has developed a panel of diverse, genetically characterized, diverse hiPSC lines manufactured under ISSCR research standards, including disease-specific variants such as APOE ε4/ε4, APP KM670/671NL (Alzheimer’s disease), and ABCA4 knockout (Stargardt disease). This session presents characterization data for differentiated models derived from our healthy control hiPSC lines, including forebrain neuron precursor cells (demonstrating electrophysiological activity, synaptic connectivity, and region-specific marker expression), astrocytes (exhibiting mature functional marker profiles), and retinal pigment epithelial (RPE) cells (demonstrating cellular polarization, barrier integrity, and phagocytic activity). Learn how these differentiated cells and organoids, generated using optimized STEMdiff™ protocols, accelerate research by providing physiologically relevant, ready-to-use models with diverse genetic backgrounds. Discover how STEMCELL’s platforms enable precise disease modeling, efficient drug screening, and detailed mechanistic studies.