Exhibit Hall Theater Talks

THE ROAD TO SCALABLE MANUFACTURING: CHALLENGES AND INNOVATIONS

Mesenchymal stem cells (MSCs) hold immense promise in regenerative medicine due to their immunomodulatory and therapeutic potential. However, transitioning from laboratory research to large-scale manufacturing presents significant challenges, including maintaining cell quality, consistency, and scalability. Stirred-tank bioreactors (STRs), such as those developed by Applitech, provide a scalable and controlled platform for MSC expansion, addressing these challenges while ensuring reproducibility and efficiency. This talk will highlight the use of Applitech's STR systems for MSC manufacturing, focusing on key process parameters such as media optimization using InnoCellular’s proprietary MesenPlify™ media and dynamic control of culture conditions. These strategies ensure the preservation of MSC functionality and therapeutic properties during scale-up. By leveraging the advantages of STR technology and optimized media formulations, this approach enables efficient and reproducible production of high-quality cells. This advancement aims to meet the growing demands of clinical applications, paving the way for scalable and cost-effective cell-based therapies.