Post-doctoral Fellow Centre for Translational Stem Cell Biology / The university of Hong Kong hongkong, Hong Kong
Abstract: A Novel Human Cellular System for Studying Normal Ageing and Anti-ageing Discovery Zhen Feng, Ph.D., Zhuoxuan Li, Ph.D. and Pentao Liu, Ph.D. Centre for Translational Stem Cell Biology The University of Hong Kong Ageing is a complex biological process with profound health implications. Scientists have relied on model organisms such as fly and mouse and cellular models that lack normal human physiology-specific relevance. The placenta trophoblast development is an accelerated aging process, and provides unique insights into ageing. We have developed a pioneering technology for aging research: an ageing-emulated biosystem based on the development of human trophoblast stem cells to syncytiotrophoblasts. The biosystem displays all major ageing hallmarks, such as cell cycle arrest, genomic instability, epigenetic modifications, telomere attrition, and SASP, thereby establishing an accelerated ageing model in human normal cells. This robust technology enables simple, rapid and quantitative detection of potential anti-aging activities and thus holds promise for advancing ageing study, expediting anti-ageing discovery, and improving human health and longevity.
Funding Source: This research is supported by Health@InnoHK, the Innovation and Technology Commission of the Government of the HKSAR.
