Phd Student Nagoya University, Heilongjiang, China (People's Republic)
Abstract: Aging significantly contributes to the development of many degenerative diseases, with the most visible effects appearing on the skin, particularly in the form of photoaging caused by ultraviolet (UV) light exposure. This complex process results from the synergistic action of multiple mechanisms. The lack of effective therapeutic options poses a major challenge for current research. Our previous studies have demonstrated that human dental pulp stem cell-derived small extracellular vesicles (hDPSC-sEV) protect submandibular gland ductal cells from X-ray-induced long-term progression of senescence. Here, we aim to ascertain whether hDPSC-sEV exerts a therapeutic effect on photoaging. Senescence of human dermal fibroblasts (hHDFs) was induced in vitro using ultraviolet radiation B (UVB). The EV-treated group exhibited enhanced cell proliferation in a concentration-dependent manner. Furthermore, EVs markedly improved the migration and wound healing capabilities of the cells. Notably, EVs reduced the expression of the senescence marker SA-β-Gal and facilitated the repair of DNA damage. In conclusion, hDPSC-sEVs have the potential to enhance the physiological function of photoaged cells and delay the aging process, making them promising candidates for therapeutic applications.
