Abstract: While the clinical development of cell therapy products using human stem cells is progressing, in their manufacturing, materials such as culture media and growth factors, in addition to the manufacturing process, significantly contribute to manufacturing efficiency and product quality. With the improvement of culturing methods, animal origin free culture media for iPS cells have been developed. However, the manufacturing methods often follow laboratory procedures, and in the case of culture media products, not only the composition but also the form, supply, and storage of the products remain unchanged, leading to cases where they are unsuitable for large-scale manufacturing of cell therapy products. In this presentation, we will discuss the advantages of optimizing not only the composition but also the form of culture media products, which have been optimized in the laboratory, for large-scale manufacturing of clinical cell therapy products.
