Postdoctoral The University of Hong Kong, United States
Abstract: Aging is a complex biological process whose underlying mechanisms remain inadequately understood. With the global population of older adults on the rise, it is imperative to deepen our understanding of the aging process. GeneA is a multifunctional protein that serves as a DNA and RNA binding factor, regulating gene expression at the transcriptional, splicing, and translational levels. Previous studies have shown a significant decline in GeneA expression across six mouse tissues with aging; conversely, caloric restriction—a known intervention that mitigates aging—can restore GeneA levels. However, the precise role of GeneA in aging, particularly in humans, remains elusive. In this study, we employed a well-established trophoblast aging model, utilizing the differentiation of trophoblast stem cells (TSCs) into syncytiotrophoblasts (STBs), to elucidate the emerging role of GeneA as a novel anti-aging marker.
