Research Assistant & PhD student Hong Kong University & Centre for translational stem cell biology limited, Hong Kong
Abstract: Trophoblast development is essential for a successful pregnancy, as these cells form the outer layer of the blastocyst and facilitate the embryo's attachment to the uterus, leading to placenta formation. The placenta plays a critical role in supplying nutrients and oxygen to the fetus. Cytotrophoblasts differentiate into two main types: Extravillous trophoblasts (EVTs) and syncytiotrophoblasts (STBs), which are crucial for releasing hormone and remodelling blood vessels to support fetal development. Abnormal trophoblast development can result in serious pregnancy complications, including preeclampsia, intrauterine growth restriction, and preterm labor. Angiotensin-converting enzyme 2 (ACE2) is an enzyme that regulates blood pressure and has protective effects against cardiovascular and renal diseases. It is part of the Renin- Angiotensin System (RAS), which manages blood pressure and fluid balance. In pregnancy, ACE2 is expressed in the placenta and plays a vital role in regulating blood flow to the fetus. During the COVID-19 pandemic, ACE2 gained attention as the entry point for the virus in various cells. In this study, we utilized an in vitro placental model derived from human Extended Potential Stem Cells (hEPSCs) to investigate ACE2's function in trophoblast development. We find that ACE2 functions in trophoblast development at both pre- implantation and post-implantation stages. Further understanding ACE2's role in placental biology could provide insights into managing pregnancy complications and infectious diseases.
Funding Source: This project is supported by Health@InnoHK, Innovation Technology Commission, HKSAR
