Post-doc Fellow Centre for Translational Stem Cell Biology Hong Kong, Hong Kong
Abstract: Trophoblast stem cell and their progenitor cells are critical for pregnancy establishment and maintenance, yet their vulnerability to viral infections has been inadequately explored. This study examines the interactions between the Influenza virus and human trophoblast cells, highlighting the cells' significant susceptibility to the virus. We demonstrate that trophoblasts facilitate Influenza virus entry and support extensive viral replication, suggesting their potential as an effective model for viral infection studies. By utilizing this model, we performed rapid drug screening, identifying compounds within 24 hours post-infection that are safe and effective against Influenza, COVID-19, and Monkeypox. These findings not only shed light on trophoblasts' interaction with viral pathogens but also introduce a promising avenue for accelerating the development of antiviral agents. Our research opens new opportunities for addressing the global health challenge posed by emerging diseases like Monkeypox, highlighting the importance of rapid screening platforms in the fight against viral infections.
Funding Source: Funding support from Health@InnoHK, Innovation and Technology Commission
